PPARγ phase separates with RXRα at PPREs to regulate target …
WEBApr 26, 2022 · Peroxisome proliferator-activated receptor (PPAR)-γ is a key transcription activator controlling adipogenesis and lipid metabolism. PPARγ binds PPAR response...
PPARγ lipodystrophy mutants reveal intermolecular ... - Nature
WEBNov 19, 2022 · Peroxisome proliferator-activated receptor γ (PPARγ) is the master regulator of adipocyte differentiation, and mutations that interfere with its function cause lipodystrophy. PPARγ is...
Computational identification and experimental validation of PPRE motifs ...
WEBDec 3, 2009 · Our results computationally predicted the presence of 2 PPRE motifs in NHE1 and 3 PPRE motifs in MnSOD. We experimentally confirmed the true motifs and their regulation by PPAR. Our results suggest that both NHE1 and MnSOD have PPRE binding motif in their upstream/promoter region and …
An Ideal PPAR Response Element Bound to and Activated by PPARα
WEBAug 4, 2015 · Peroxisome proliferator-activated receptor-α (PPARα), a nuclear receptor, plays an important role in the transcription of genes involved in fatty acid metabolism through heterodimerization with the retinoid x receptor (RXR).
Genome-wide identification of peroxisome proliferator response …
WEBNov 11, 2005 · Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors that serve as cellular sensors of fatty acids and fatty acid derivatives and broadly regulate nutrient metabolism and energy homeostasis.
Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA
WEBNov 20, 2008 · Both receptors’ ligands, including rosiglitazone for PPAR-γ and 9-cis-retinoic acid for RXR-α, the DNA response element (PPRE) and coactivator peptides were included to examine how all the ...
PPARγ lipodystrophy mutants reveal intermolecular interactions …
WEBNov 19, 2022 · Peroxisome proliferator-activated receptor γ (PPARγ) is the master regulator of adipocyte differentiation, and mutations that interfere with its function cause lipodystrophy. PPARγ is a highly modular protein, and structural studies indicate that PPARγ domains engage in several intra- and inter-molecular interactions.
A novel peroxisome proliferator response element modulates …
WEBDec 15, 2015 · We investigated the function of a putative peroxisome proliferator-activated receptor (PPAR)-response element (PPRE) sequence motif located at -768 to -752 bases upstream of the transcription start site of human LDLR gene in response to PPARδ activation.
Computational identification and experimental validation of PPRE motifs …
WEBDec 3, 2009 · Results: Our results computationally predicted the presence of 2 PPRE motifs in NHE1 and 3 PPRE motifs in MnSOD. We experimentally confirmed the true motifs and their regulation by PPAR.
Identification of novel PPARγ target genes by ... - ScienceDirect
WEBJul 25, 2008 · The right column shows a two-gradation heat map of genes containing computationally detected PPRE consensus sequences. The brighter fields denote matches to known PPREs, whereas darker fields represent predicted PPRE motifs.