Evolutionary link between metazoan RHIM motif and prion
WEBDec 11, 2014 · The Rip homotypic interaction motif (RHIM) is a short, non-globular sequence stretch that mediates a key interaction of mammalian necroptosis signaling.
Death, TIR, and RHIM: Self‐assembling domains involved in innate ...
WEBDec 5, 2018 · The ‘RIP homotypic interaction motif’ (RHIM) is a short sequence of ∼15–20 amino acids, first identified as a homotypic interaction motif that facilitates association between RIP1 and RIP3. 115 Located at the C-terminus of RIP3 and adjacent to the C-terminal DD in RIP1, the RHIM domain forms …
RHIMoving fibrils of death | Cell Research - Nature
WEBSep 12, 2023 · The RHIM is a conserved ~18 amino acid motif that comprises a tetrad sequence (I/V)-Q- (I/V/L)-G flanked by hydrophobic sequences. 2 Interacting RHIMs adopt a cross-β-sheet configuration...
ZBP1 condensate formation synergizes Z-NAs recognition and …
WEBJul 9, 2024 · Furthermore, ZBP1 RHIM domains show typical amyloidal fibril characterizations and cross-polymerize with RIPK1 depending on the core motif of 206 IQIG 209, while mutated ZBP1 could impede...
ZBP1-Mediated Necroptosis: Mechanisms and Therapeutic …
WEBDec 21, 2022 · ZBP1 contains two N-terminal ZBDs (Zα1 and Zα2), at least two RIP homotypic interaction motif domains (RHIM1 and RHIM2), and one C-terminal signal domain (SD) (Figure 1) . Zα2 domain plays a key role in sensing Z-DNA and Z-RNA.
RHIM-based protein:protein interactions in microbial defence against ...
WEBMar 1, 2020 · The Receptor-interacting protein kinase Homotypic Interaction Motif (RHIM) is an amino acid sequence that mediates multiple protein:protein interactions in the mammalian programmed cell death pathway known as necroptosis.
CDD Conserved Protein Domain Family: RHIM - National Center …
WEBSep 29, 2021 · The RHIM domain is necessary for the recruitment of RIP and RIP3 by the IFN-inducible protein DNA-dependent activator of IRFs (DAI), also known as DLM-1 or Z-DNA binding protein (ZBP1). Both the RIP kinases contribute to DAI-induced NF-kappaB activation. RIP3 undergoes auto phosphorylation on binding to DAI.
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction ...
WEBJul 10, 2009 · Here, we report the identification of two receptor‐interacting protein (RIP) homotypic interaction motifs (RHIMs) in the DAI protein sequence, and show that these domains relay DAI‐induced NF‐κB signals through the recruitment of the RHIM‐containing kinases RIP1 and RIP3.
PANoptosis: Emerging mechanisms and disease implications
WEBNov 15, 2023 · ZBP1, also known as DNA-dependent activator of IFN-regulatory factors (DAI) and DLM-1, is a unique innate immune sensor which harbors two N-terminal Z-nucleic acid-binding domains (ZBD, Zα1 and Zα2), two receptor-interacting protein homotypic interaction motif (RHIM, RHIM1 and RHIM2), and a functionally undefined C-terminal region (Fig. 2 ...
ZBP1 promotes LPS-induced cell death and IL-1β release via
WEBJan 4, 2021 · ZBP1 is a RHIM (RIP homotypic interaction motif) domain-containing protein, which has been shown to mediate various forms of cell death via interactions with other RHIM domain-containing proteins...
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