Mescal is a Census-designated place located in Cochise County, Arizona, United States. Mescal was originally a populated place, at a rail station on the Southern Pacific Railroad at an elevation of 4,085 feet. The modern community lies to the south of the railroad near Interstate 10, at 4,170 feet. Mescal had a population of 1,812 in the 2010 Census. Mescal had a …Mescal is a Census-designated place located in Cochise County, Arizona, United States. Mescal was originally a populated place, at a rail station on the Southern Pacific Railroad at an elevation of 4,085 feet. The modern community lies to the south of the railroad near Interstate 10, at 4,170 feet. Mescal had a population of 1,812 in the 2010 Census. Mescal had a post office from 1913 until 1931.