The Lions are 4-0-1 in the last 5 meetings. Quarterback Kyler Murray has not beaten the Lions yet in his career. The closest he came was his NFL debut, when he rallied the Cardinals from 18 points down to finish in a tie.

The Arizona Cardinals' Week 3 opponent at State Farm Stadium Sunday afternoon are the 1-1 Detroit Lions, who are favored to win the game. Both teams are 1-1 and both teams' wins came against the L.A.