If Kittle does miss Sunday's game, he will join star running back Christian McCaffrey, who is currently on the Injured Reserve list with a calf injury and Achilles tendonitis. Wide receiver Deebo Samuel is also missing time following a calf injury he suffered in Week 2. Quarterback Brock Purdy is running low on targets to throw to.

Already without two of their most important players, the San Francisco 49ers added two more key names to the injury report Thursday when tight end George Kittle and cornerback Charvarius Ward did not participate in practice.

George Kittle could have to miss his first game of the season as the San Francisco 49ers take on the Los Angeles Rams on Sunday. Per ESPN's Adam