Injuries will leave quarterback Brock Purdy on the sideline with veteran signal caller Brandon Allen slated to start in his stead. While Allen’s start will make an already tough game more difficult for the 49ers, it could facilitate some offensive innovation from a group that was starting to get stagnant on that side of the ball.

The Green Bay Packers won't have to defend Brock Purdy or block Nick Bosa when the San Francisco 49ers arrive at Lambeau Field on Sunday. Kyle Shanahan's team ruled out both players on the final injury report delivered Friday afternoon.

The San Francisco 49ers ruled out starting quarterback Brock Purdy because of a shoulder injury and announced backup Brandon Allen as the starter for Sunday's showdown with the Green Bay Packers.

The Buffalo Bills defense could be catching a break as San Francisco 49ers quarterback Brock Purdy may not play in their Week 13 showdown.

San Francisco 49ers quarterback Brandon Allen will start for injured starter Brock Purdy on Sunday at the Green Bay Packers, per head coach Kyle Shanahan

Here are five things to watch and a prediction for Week 12:

The San Francisco 49ers will go into Week 12 without quarterback Brock Purdy and defensive end Nick Bosa. Head coach Kyle Shanahan on Friday told reporters both players have been ruled out against the Green Bay Packers. Purdy is nursing a shoulder injury ...

Sunday's showdown at Lambeau Field may not come down to which side has the better team, but rather which squad better handles its many injuries.