GLP-1–pathway agonists such as semaglutide and newer multi-agonists have transformed care for obesity and diabetes, yet developers still wrestle with durability, tissue targeting, and signal "bias." ...

Peroxidases are enzymes that break down hydrogen peroxide in organisms. Since their discovery in 1998, the electron source of ...

A team has used neutron crystallography to image all of the atoms in a radical intermediate of a copper amine oxidase enzyme. They disclosed previously unknown details, such as precise conformational ...

Using a series of more than 1,000 X-ray snapshots of the shapeshifting of enzymes in action, researchers at Stanford University have illuminated one of the great mysteries of life – how enzymes are ...

Chemists from the National University of Singapore (NUS) have developed a way to make diverse chiral deoxyribonucleic acid (DNA) catalysts by merging DNA repair with biorthogonal chemistry, paving the ...

Ever since it flooded our planet’s atmosphere more than 2.1 billion years ago, oxygen has played a starring role in our lives. But despite its crucial importance to the function of all living ...

For the first time, researchers have successfully used computational simulations to modify an enzyme’s structure to increase the optimum temperature of a reaction. Researchers at Uppsala University ...

The team genetically engineered fruit flies to make naked mole rat cGAS and found that they lived 70 days—10 days longer than ...

Man prides himself upon his growing mastery over nature, but in the ultimate biochemical analysis nature remains the master of man. With their most sophisticated laboratory glassware and corrosive ...

Osaka, Japan – When your wounds heal and your liver detoxifies a poison such as histamine you ingested, you can thank the class of enzymes known as copper amine oxidases for their assistance.