If the Bills do clinch the AFC East on Sunday, they'd be the earliest team to win a division since the New Orleans Saints won the NFC South during Week 13 of the 2019 season. Buffalo sits in the two-seed in the AFC playoff picture and is still well in the hunt to chase down Kansas City for the top spot and first-round bye.

It’s Week 13 in the NFL, and the Buffalo Bills have a chance to secure their fifth consecutive AFC East title, setting a new franchise record. For this to happen, Buffalo (9-2) first needs the Miami Dolphins (5-6) to fall to the Green Bay Packers on Thanksgiving night. Then, the Bills must defeat the San Francisco 49ers on Sunday Night Football.

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game

The Buffalo Bills are fresh off of their bye week heading into a Sunday Night Football matchup with the San Francisco 49ers, who are in serious danger of missin

The San Francisco 49ers had their ugliest loss of the year on Sunday, dropping a 38-10 game to the Green Bay Packers to fall to 5-6 on the season. After a close 20-17 loss to the Seattle Seahawks in Week 11 where the 49ers were in control for much of the game,