The 49ers just beat the Indianapolis Colts 48-27 and won their 11th game of the season. Last season, they lost 11 games.

The 49ers on Monday night did what they had to do to keep their hopes of the No. 1 seed alive.The offense did most of the ...

San Francisco 49ers head coach Kyle Shanahan talks to the media after Week 16 win against the Indianapolis Colts about goals ...

Purdy is the first Niners quarterback to throw five touchdown passes in a game since Steve..

The San Francisco 49ers finished their Week 16 "Monday Night Football" contest with a 48-27 win over the Indianapolis Colts ...

The 49ers had three players deal with injuries on Monday night against the Colts. Here's what Kyle Shanahan said about ...

Brock Purdy and the 49ers turned it up a notch against the Colts to close out Week 16, despite having already clinched a ...

The San Francisco 49ers may win their Week 16 matchup with the Indianapolis Colts, but they lost one of their best players to ...

The San Francisco 49ers were healthy in the first quarter against the the Indianapolis Colts, but the injuries are piling up ...

There have been multiple moments over the past several months where the thought of this San Francisco 49ers team being a number one seed in the playoffs ...

San Francisco 49ers running back Christian McCaffery catches a 2-yard pass from quarterback Brock Purdy for a..

The 49ers had already ruled out wide receiver Ricky Pearsall, who missed practice all week with knee and ankle injuries."He ...