The 49ers on Monday night did what they had to do to keep their hopes of the No. 1 seed alive.The offense did most of the ...

The San Francisco 49ers finished their Week 16 "Monday Night Football" contest with a 48-27 win over the Indianapolis Colts ...

Purdy is the first Niners quarterback to throw five touchdown passes in a game since Steve..

San Francisco 49ers head coach Kyle Shanahan talks to the media after Week 16 win against the Indianapolis Colts about goals ...

Brock Purdy and the 49ers turned it up a notch against the Colts to close out Week 16, despite having already clinched a ...

The 49ers had three players deal with injuries on Monday night against the Colts. Here's what Kyle Shanahan said about ...

Brock Purdy throws five touchdowns as the 49ers dominate the Colts, earning praise from Kyle Shanahan for a near-perfect performance.

The San Francisco 49ers climb the NFC standings with a win over the Indianapolis Colts, keeping home-field advantage and NFC West title within reach.

Key stats from the 49ers' 48-27 Week 16 win over the Colts, highlighted by Brock Purdy's 5 TDs, Christian McCaffrey's big night, and MNF history.

San Francisco 49ers running back Christian McCaffery catches a 2-yard pass from quarterback Brock Purdy for a..

The San Francisco 49ers were healthy in the first quarter against the the Indianapolis Colts, but the injuries are piling up ...

The San Francisco 49ers may win their Week 16 matchup with the Indianapolis Colts, but they lost one of their best players to ...