ESPN's "Monday Night Football" matchup will have a major impact on both the AFC and NFC playoff pictures. Here's what to know about the Week 16 game.

Who is playing on Monday Night Football? Check out the complete MNF game schedule, including Rams vs Falcons matchup for NFL Week 17 game on Dec. 29.

San Francisco aims to improve playoff position while Indianapolis fights for postseason hopes with Philip Rivers at quarterback. Here's how to watch for free.

Daily Fantasy multimillionaire Mike McClure reveals his daily Fantasy football picks for Indianapolis vs. San Francisco on 'MNF'

The San Francisco 49ers, on a four-game winning streak, try to stay hot Monday night against an Indianapolis Colts team on a four-game losing streak.

Brock Purdy, who threw a career-high five touchdowns, and the 49ers pulled away from the Colts on Monday night for a 48-27 win.

Apart from being two of ESPN’s top reporters, Rutledge and Kimes have also emerged as fashion icons among fans. Ahead of Monday’s kickoff, Kimes took to social media to share a photo of their accidentally coordinated outfits for “Monday Night Football.”

The Arizona Cardinals held a top-five draft position for all of 24 hours before Monday Night Football pushed them down the order. After their Week 16 loss to the Atlanta Falcons, the Cardinals moved up from No.

How to watch, listen to and live stream the Rams' Week 17 Monday Night Football matchup against the Atlanta Falcons on Dec. 29.