Meaning, whether you lose weight through a change in your diet, a different medication, or bariatric surgery, there is a risk of losing bone density. However, in this particular study, taking weight loss drugs like Ozempic did seem to have a bigger impact on bone density than losing weight through other means.

Natural supplements have “very mild effects” on weight loss based on what Dr. Ali has seen. There is some data to suggest that saffron, green tea, or turmeric can have a slight impact on GLP-1 production, he says, but again, it's not a ton.

Prescribed medications like Ozempic and Wegovy can be expensive and hard to find, leading to a rise in popularity of natural weight-loss alternatives — but do they really work, and are they safe? NBC’s Emilie Ikeda reports and gastroenterologist Dr.