Normally, the SOD1 protein provides protective benefits to the brain but, in Parkinson’s patients, it becomes faulty, causing the protein to clump and damage brain cells.

Normally, the SOD1 protein provides protective benefits to the brain but, in Parkinson's patients, it becomes faulty, causing the protein to clump and damage brain cells.

Wild-type SOD1 exists as a dimer with bound Cu and Zn, while mutants are misfolded, unable to dimerize or unable to efficiently bind Zn. a, Mutant SOD1 toxicity may result from aberrant oxidative ...

Australian researchers first found abnormal SOD1 in Parkinson's patients' brains in 2017. While normally protective, this protein becomes defective in the disease, clumping and harming brain cells ...

A new drug originally developed to treat a different brain disease is now showing signs that it could help people with ...

As reported in 1994, the original SOD1-G93A strain, designated G1, expressed approximately 18 copies of human SOD1, randomly inserted into the genome (Gurney et al., 1994). An unequal crossover event ...

Now, scientists at the University of Sydney have made an exciting discovery: they’ve found a new brain protein linked to Parkinson’s and figured out how to modify it. This could help lead to new and ...

SOD1-NS, non-stimulated SOD1 carrier mice; SOD1-S, stimulated SOD1 carrier mice; WT, wild-type mice. We also calculated the survival time from birth for control and stimulated animals. As shown in ...

Copper, zinc superoxide dismutase (SOD1) is activated in vivo by the copper chaperone for superoxide dismutase (CCS). The molecular mechanisms by which CCS recognizes and docks with SOD1 for metal ion ...

A total of 87 subjects (45 men and 42 women) with an age range from 16–73 years of age were studied. RESULTS There was no detectable difference in the number of motor units in SOD1 mutation carriers ...