Transcription activation of genes by estrogens is driven by enhancers, which are often located within the same Topologically Associating Domain (TAD) as non-targeted promoters. We investigated how ...

No writing assistance was utilized in the production of this manuscript. Monoclonal antibodies are novel therapeutic agents used with great success in the treatment of rheumatoid arthritis (RA).

Researchers at Fred Hutchinson Cancer Center, led by Dr. Julie McElrath, Director of the Vaccine and Infectious Disease Division, have found a new way to train our immune system to make antibodies ...

Three washes were given for 5 minutes each (3*5’) in phosphate buffer. All antibodies except FGFR3 and PDGFRα required antigen retrieval at 90°C–95°C in 10 mM sodium citrate buffer (pH 6.0) for 10 min ...

Deciding on antigen vs. antibody tests when choosing a COVID-19 test is easier when the definitions and their function are clear. These tests represent different ways you can check for SARS-CoV-2, the ...

For example, the high-risk HPV E6 protein degrades KDM5C in cervical cancer cells, which results in super enhancers activation of the proto-oncogenes c-MET and EGFR by changing the H3K4me3/H3K4me1 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Circadian rhythmicity of gene expression is a ...

Background Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for ...

1 Department of Blood Transfusion, Changzhou Hospital of Traditional Chinese Medicine, Changzhou, Jiangsu, China 2 Department of Laboratory Medicine, Northern Jiangsu People’s Hospital Affiliated to ...

1 Innovation Laboratory, Volition America, Carlsbad, CA, United States 2 Department of Developmental Biology and Cancer Research, The Hebrew University of Jerusalem, Jerusalem, Israel Background: ...