In some areas, up to 36 inches of snow could accumulate, with winds reaching speeds of up to 55 mph. The hazardous conditions are expected to significantly impact Thanksgiving travel, with reduced visibility and snow-covered roads making driving conditions treacherous.

A storm pounding California's Sierra Nevada mountains with snow Tuesday was taking aim at the Colorado Rockies and could roll east and slam the Appalachians on Thanksgiving Day, bringing unsettling travel weather to millions of Americans hitting the skies and roads for the holiday weekend.

Multiple winter storm warnings and advisories are in place across the country, with cold weather expected to bring travel chaos.