The San Francisco 49ers will be without a couple of key players Sunday, but their troubles pale in comparison with the ...

San Francisco 49ers quarterback Brock Purdy isn't letting early-season injuries shake his confidence. Although he has been ...

San Francisco 49ers safety Talanoa Hufanga is poised to make his season debut on Sunday against the Los Angeles Rams.

The 49ers added tight end George Kittle (hamstring), cornerback Charvarius Ward (hamstring/knee) and edge rusher Nick Bosa ...

George Kittle and Charvarius Ward not practicing Thursday could mean the San Francisco 49ers will be missing four All-Pros ...

Videos are auto-populated by an affiliate. This site has no control over the videos that appear above. The San Francisco ...

Football, they say, is a war of attrition. For the 49ers and the Rams, attrition has arrived with a capital A.The latest name ...

San Francisco 49ers running back Christian McCaffrey will practice on Wednesday, though he will once again be limited.

The San Francisco 49ers have provided new injury updates ahead of Thursday's practice, adding two more key players to the ...

The 49ers will face the Rams on Sunday, for the first time since first-ballot, Deion-Sanders-Upper-Room Hall of Famer Aaron ...

The San Francisco 49ers suddenly have a host of injury problems, and it's reflected on their second practice report of ...

Derek Carr, Kyler Murray and C.J. Stroud are among the players making big moves in Nick Shook's QB Index rankings entering ...