World TB Day, March 24, marks the day in 1882 that Robert Koch announced the discovery of Mycobacterium tuberculosis, responsible for the ancient disease now known as tuberculosis (TB). The disease ...

I commend Florian A Wenzl and colleagues for extending the use of the Global Registry of Acute Coronary Events (GRACE) 3.0 ...

Clinical decision support (CDS) software plays an increasingly central role in health-care delivery, yet the ambiguous interpretations of regulations result in inconsistent application in clinical ...

Each year, an estimated 1·9 million children (aged 0–9 years) and adolescents (aged 10–19 years) develop tuberculosis disease ...

Tuberculosis remains a major global health threat, and symptom-based case detection fails to interrupt community transmission.1 Nearly half of tuberculosis cases are missed by current strategies, and ...

Preliminary results from the long-awaited COLOR III trial by Jurriaan Tuynman and colleagues, published in The Lancet Gastroenterology & Hepatology, show that transanal total mesorectal excision ...

Despite continuous improvements in sepsis outcomes over past decades, data suggest that overall prognosis has plateaued.1 Specifically, septic shock—a severe form of sepsis characterised by systemic ...

Bronchiolitis remains the leading cause of hospital admission in infancy and of paediatric intensive care unit use.1 Management of bronchiolitis has been largely limited to supportive care, reflecting ...

Type 1 diabetes confers a cardiovascular burden that is often obscured by the young age of affected individuals and by the ...

Clinical trial datasets are becoming increasingly complex, yet the format of their dissemination remains largely static.1 ...

Urinary stone disease is common, associated with substantial morbidity, has a high recurrence rate, and affects quality of life.1,2 Consumption of large volumes of fluids is a foundational strategy ...

Among today's most pressing development challenges is the matching of financing to health needs. One of the critically underfunded global priorities is adolescent health, with adolescents (aged 10–24 ...