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Rose Apple on Instagram: "💐 Chediak–Higashi Syndrome (CHS)💐 💐Chediak–Higashi syndrome is a rare inherited immunodeficiency disorder transmitted in an autosomal recessive pattern. 👉 It is caused by mutations in the LYST gene (lysosomal trafficking regulator). 💐 Pathophysiology ✅ Defective lysosomal trafficking and fusion ✅ Formation of giant abnormal granules in leukocytes, especially neutrophils ✅ Impaired phagocytosis and intracellular killing of microorganisms 💐Hematologic Findings ✅ Gia